Technical Data
Z0728-50B
ZMPSTE24 (Zinc Metalloproteinase Ste24 Homolog, CAAX Prenyl Protease 1 Homolog, Farnesylated Proteins Converting Enzyme 1, FACE 1, FACE1, FACE-1, FLJ14968, MADB, Prenyl Protein Specific Endoprotease 1, STE24)
Description:
ZMPSTE24 is a zinc metalloprotease involved in the post-translational processing of LMNA precursors. Mutations in ZMPSTE24 have been associated with human diseases, often due to the accumulation of LMNA precursors. It is possible that ZMPSTE24, due to its association with LMNA, plays some role in human ageing.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C. Aliquots are stable for at least 3 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanGoat
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide, C-ERLQALKTMKQH, representing the C Terminus of the human protein according to NP_005848.2. Homology: Human
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA.
Specificity:
Recognizes human ZMPSTE24.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.Science. 2006 Mar 17;311(5767):1621-3. Epub 2006 Feb 16. PMID: 16484451