Technical Data

029370
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Conjugate
FITC
Isotype
IgG
Grade
Affinity Purified
Applications
FLISA WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SNX3 (Sorting Nexin-3, Protein SDP3) (FITC)

Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G By similarity. Not involved in EGFR degradation.

Applications
Suitable for use in FLISA and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Immunogen
Recombinant corresponding to human SNX3.
Form
Supplied as a liquid in PBS. Labeled with fluorescein isothiocyanate (FITC).
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human SNX3.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. "Identification of a family of sorting nexin molecules and characterization of their association with receptors." Haft C.R., de la Luz Sierra M., Barr V.A., Haft D.H., Taylor S.I. Mol. Cell. Biol. 18:7278-7287 (1998). 2. "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P." Xu Y., Hortsman H., Seet L., Wong S.H., Hong W. Nat. Cell Biol. 3:658-666. 3. "Homo sapiens sorting nexin 3A (SNX 3A) mRNA." Hayama A., Uchida S., Sasaki S., Marumo F. 4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45 (2004).
USBio References
No references available
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