Technical Data

030769
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1,k
Clone Number
147CT8.3.4
Grade
Affinity Purified
Applications
E IF IHC WB
Crossreactivity
Hu
Gene ID
4329
Gene #
ALDH6A1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-ALDH6A1 (ALDH6A1, MMSDH, Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, Aldehyde dehydrogenase family 6 member A1)
ALDH6A1, MMSDH, Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, Aldehyde dehydrogenase family 6 member A1

This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100~500 Immunohistochemistry: 1:50~100 Immunofluorescence: 1:10~50
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
ALDH6A1 antibody is generated from mouse immunized with ALDH6A1 recombinant protein.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.|Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.|Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34. Kuiper H, et al. Cytogenet Genome Res, 2005. PMID 15909363.|The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.|The human plasma proteome: a nonredundant list developed by combination of four separate sources. Anderson NL, et al. Mol Cell Proteomics, 2004 Apr. PMID 14718574.
USBio References
No references available
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