Technical Data

030792
Clone Type
Monoclonal
Host
Mouse
Source
Mouse
Isotype
IgG1,k
Clone Number
287CT12.2.2
Grade
Ascites
Applications
E WB
Crossreactivity
Mo
Accession #
NP_116241.2; NP_835739.1;
Gene ID
84938
Gene #
ATG4C
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-ATG4C (ATG4C,Cysteine protease ATG4C,APG4C, AUTL1, AUTL3)
ATG4C,Cysteine protease ATG4C,APG4C, AUTL1, AUTL3

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq].

Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1000 Western Blot: 1:100~8000
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ATG4C Mab is generated from mouse immunized with ATG4C recombinant protein.
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Ascites
Specificity
Mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Kathiresan, S., et al. Nat. Genet. 40(2):189-197(2008)|Marino, G., et al. J. Biol. Chem. 282(25):18573-18583(2007)|Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007)|Marino, G., et al. J. Biol. Chem. 278(6):3671-3678(2003)
USBio References
No references available
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