030963
Clone Type
MonoclonalHost
MouseSource
HumanIsotype
IgG1Clone Number
546CT11.4.3Grade
AscitesApplications
E WBCrossreactivity
HuAccession #
NP_068656Gene ID
2266Gene #
FGGShipping Temp
Blue IceStorage Temp
-20°CMouse Anti-FGG (FGG, Fibrinogen gamma chain)
FGG, Fibrinogen gamma chain
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:200~1600
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
FGG Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human FGG.
Form
Supplied as a liquid, 0.09% sodium azide.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Bahadori, B., et al. Thromb. Res. 126(4):350-352(2010)|Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Fujihara, N., et al. Thromb. Haemost. 104(2):213-223(2010)|Undas, A., et al. Thromb. Haemost. 104(2):415-417(2010)|Davila, S., et al. Genes Immun. 11(3):232-238(2010)USBio References
No references available