Technical Data

031029
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1
Clone Number
622CT11.9.6
Grade
Ascites
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000536.4
Gene ID
6927
Gene #
HNF1A
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-HNF1A (HNF1A, TCF1, Hepatocyte nuclear factor 1-alpha, Liver-specific transcription factor LF-B1, Transcription factor 1)
HNF1A, TCF1, Hepatocyte nuclear factor 1-alpha, Liver-specific transcription factor LF-B1, Transcription factor 1

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas.

Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1?100~1600
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
HNF1A Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human HNF1A.
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Ascites
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)|Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)|Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)|Ley, S.H., et al. Cardiovasc Diabetol 9, 39 (2010)|Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net