Technical Data

031093
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgM
Clone Number
399CT9.3.4
Grade
Ascites
Applications
E WB
Crossreactivity
Hu
Accession #
NP_033666.1; NP_002332.1
Gene ID
4050
Gene #
LTB
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-LTB, CT (LTB, TNFC, TNFSF3, Lymphotoxin-beta, Tumor necrosis factor C, Tumor necrosis factor ligand superfamily member 3)
LTB, TNFC, TNFSF3, Lymphotoxin-beta, Tumor necrosis factor C, Tumor necrosis factor ligand superfamily member 3

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:2000~16000
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
LTB Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from the C-term region of human LTB.
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Ascites
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)|Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Young, J., et al. Cytokine 51(1):78-86(2010)|McGeachie, M., et al. Circulation 120(24):2448-2454(2009)|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
USBio References
No references available
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