Technical Data

031103
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgM,k
Clone Number
230CT5.3.1
Grade
Ascites
Applications
E WB
Crossreactivity
Hu
Accession #
NP_002410.1
Gene ID
4296
Gene #
MAP3K11
Shipping Temp
Blue Ice
Storage Temp
-20°C
Mouse Anti-MAP3K11 (MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase)
MAP3K11, MLK3, PTK1, SPRK, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1000 Western Blot: 1:100~500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
MAP3K11 Mab is generated from mouse immunized with MAP3K11 recombinant protein.
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Ascites
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Chen, J., et al. Oncogene 29(31):4399-4411(2010)|Liou, G.Y., et al. Biochem. J. 427(3):435-443(2010)|Mishra, P., et al. Mol. Endocrinol. 24(3):598-607(2010)|Rangasamy, V., et al. Cancer Res. 70(4):1731-1740(2010)|Velho, S., et al. Hum. Mol. Genet. 19(4):697-706(2010)
USBio References
No references available
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