031153
Clone Type
MonoclonalHost
MouseSource
HumanIsotype
IgMClone Number
439CT10.4.4Grade
PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_001138732.1Gene ID
8031Gene #
NCOA4Shipping Temp
Blue IceStorage Temp
-20°CMouse Anti-NCOA4 (NCOA4, ARA70, ELE1, RFG, Nuclear receptor coactivator 4, Androgen receptor coactivator 70kD protein, Androgen receptor-associated protein of 70kD, Ret-activating protein ELE1)
NCOA4, ARA70, ELE1, RFG, Nuclear receptor coactivator 4, Androgen receptor coactivator 70kD protein, Androgen receptor-associated protein of 70kD, Ret-activating protein ELE1
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100~250
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Purified His-tagged NCOA4 protein (fragment).
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Sadow, P.M., et al. Endocr. Pathol. 21(2):73-79(2010)|Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009)|Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)|Peng, Y., et al. Am. J. Pathol. 172(1):225-235(2008)|Bongarzone, I., et al. Genomics 42(2):252-259(1997)USBio References
No references available