031166
Clone Type
MonoclonalHost
MouseSource
MouseIsotype
IgG1,kClone Number
185CT47.6.1Grade
Affinity PurifiedApplications
WBCrossreactivity
MoAccession #
NP_001007793.1; NP_001012331.1; NP_002520.2Gene ID
4914Gene #
NTRK1Shipping Temp
Blue IceStorage Temp
-20°CMouse Anti-NTRK1 (NTRK1, MTC, TRK, TRKA, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA)
NTRK1, MTC, TRK, TRKA, High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Applications
Suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000-1:500 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant protein corresponding to mouse NTRK1 (NP_001007793).
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse NTRK1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Li, C., et al. Clin. Chim. Acta 411 (19-20), 1482-1486 (2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Brahimi, F., et al. Biochim. Biophys. Acta 1800(9):1018-1026(2010) Rao, R., et al. Mol. Cancer Ther. 9(8):2232-2242(2010) Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010)USBio References
No references available