031182
Clone Type
MonoclonalHost
MouseSource
MouseIsotype
IgG1,kClone Number
275CT1Grade
AscitesApplications
E WBCrossreactivity
MoAccession #
NP_002600.1;Gene ID
5159Gene #
PDGFRBShipping Temp
Blue IceStorage Temp
-20°CMouse Anti-PDGFR (PDGFRB, PDGFR, PDGFR1, Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, CD_antigen=CD140b)
PDGFRB, PDGFR, PDGFR1, Platelet-derived growth factor receptor beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, CD_antigen=CD140b, Flags: Precursor
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq].
Applications
Suitable for use in Western Blot, ELISA.
"Recommended Dilution
ELISA: 1:1000 Western Blot: 1:500~16000"
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Purified His-tagged PDGFR protein (fragment).
Form
Supplied as a liquid, 0.09% sodium azide.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Getachew, R., et al. Endocrinology 151(9):4356-4367(2010)|Roder, C., et al. Acta Neurochir (Wien) (2010) In press|Shim, A.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(25):11307-11312(2010)|Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)USBio References
No references available