031183
Clone Type
MonoclonalHost
MouseSource
MouseIsotype
IgG1,kClone Number
275CT1Grade
Affinity PurifiedApplications
E WBCrossreactivity
MoAccession #
NP_002600.1Gene ID
5159Gene #
PDGFRBShipping Temp
Blue IceStorage Temp
-20°CMouse Anti-PDGFR (Beta-type platelet-derived growth factor receptor,PDGFRB,)
Beta-type platelet-derived growth factor receptor,PDGFRB,
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq].
Applications
Suitable for use in Western Blot, ELISA.
Recommended Dilution
ELISA: 1:1000 Western Blot: 1:8~30
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
PDGFRB Mab is generated from mouse immunized with PDGFRB recombinant protein.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Getachew, R., et al. Endocrinology 151(9):4356-4367(2010)|Roder, C., et al. Acta Neurochir (Wien) (2010) In press|Shim, A.H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(25):11307-11312(2010)|Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010)USBio References
No references available