Technical Data

031660
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_000674.2
Gene ID
152
Gene #
ADRA2C
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-ADRA2C, CT (ADRA2C, ADRA2L2, ADRA2RL2, Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor)
ADRA2C, ADRA2L2, ADRA2RL2, Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-382 amino acids from the C-terminal region of human ADRA2C.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Chen, Q.J., et al. Clin. Biochem. 43(15):1201-1204(2010)|Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)|Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)|Gao, Y., et al. Ophthalmology (2010) In press :|Montgomery, M.D., et al. Br. J. Pharmacol. 159(4):820-830(2010)
USBio References
No references available
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