Technical Data

031730
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IF WB
Crossreactivity
Hu Mo
Accession #
NP_000374.1; NP_000649.1;
Gene ID
326
Gene #
AIRE
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-AIRE, ID (AIRE, APECED, Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein)
AIRE, APECED, Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Applications
Suitable for use in Western Blot, Immunofluorescence, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunofluorescence: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Cervato, S., et al. Clin. Endocrinol. (Oxf) 73(5):630-636(2010)|Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)|Conteduca, G., et al. Clin. Immunol. 136(1):96-104(2010)|Colome, N., et al. J. Proteome Res. 9(5):2600-2609(2010)|Gu, B., et al. Biochem. Biophys. Res. Commun. 394(2):418-423(2010)
USBio References
No references available
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