Technical Data

032053
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_056135.2
Gene ID
50649
Gene #
ARHGEF4
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-ARHGEF4, CT (ARHGEF4, KIAA1112, Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor 1)
ARHGEF4, KIAA1112, Rho guanine nucleotide exchange factor 4, APC-stimulated guanine nucleotide exchange factor 1

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ARHGEF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-599 amino acids from the C-terminal region of human ARHGEF4.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Lyons, R., et al. Leuk. Res. 34(1):109-115(2010)|Kawasaki, Y., et al. J. Biol. Chem. 284(33):22436-22443(2009)|Itoh, R.E., et al. J. Cell. Sci. 121 (PT 16), 2635-2642 (2008) :|Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)|Kuraguchi, M., et al. PLoS Genet. 2 (9), E146 (2006) :
USBio References
No references available
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