Technical Data

032125
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_057234.2
Gene ID
51676
Gene #
ASB2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-ASB2, NT (ASB2, Ankyrin repeat and SOCS box protein 2)
ASB2, Ankyrin repeat and SOCS box protein 2

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-86 amino acids from the N-terminal region of human ASB2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Heuze, M.L., et al. Blood 112(13):5130-5140(2008)|Kohroki, J., et al. FEBS Lett. 579(30):6796-6802(2005)|Heuze, M.L., et al. J. Biol. Chem. 280(7):5468-5474(2005)|Colland, F., et al. Genome Res. 14(7):1324-1332(2004)|Namciu, S.J., et al. Mamm. Genome 15(3):162-178(2004)
USBio References
No references available
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