Technical Data

032337
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000698.1
Gene ID
553
Gene #
AVPR1B
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-AVPR1B, CT (AVPR1B, AVPR3, VPR3, Vasopressin V1b receptor, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor)
AVPR1B, AVPR3, VPR3, Vasopressin V1b receptor, AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Vasopressin V3 receptor

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.

Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 289-317 in the C-terminal region of human AVPR1B, Swiss/UniProt Accession: P47901
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human AVPR1B.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. van West, D., et al. Psychiatry Res 179(1):64-68(2010) 2. Binder, E.B., et al. Arch. Gen. Psychiatry 67(4):369-379(2010) 3. Bosker, F.J., et al. Mol. Psychiatry (2010) In press : 4. van West, D., et al. Psychiatr. Genet. 19(2):102-103(2009) 5. Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
USBio References
No references available
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