Technical Data

032465
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
DB E
Crossreactivity
Hu
Accession #
NP_000624.2;
Gene ID
596
Gene #
BCL2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Bcl2, phosphorylated (S70) (BCL2, Apoptosis regulator Bcl-2)
BCL2, Apoptosis regulator Bcl-2

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].

Applications
Suitable for use in Dot Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Dot blot 1:500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Phospho-bcl-2-S70 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S70 of human bcl.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Feng, H., et al. Cancer Cell 18(4):353-366(2010)|Azad, N., et al. Ann. N. Y. Acad. Sci. 1203, 1-6 (2010) :|Dubikov, A.I., et al. Scand. J. Rheumatol. 39(5):368-372(2010)|Yu, B., et al. J. Exp. Clin. Cancer Res. 29, 107 (2010) :|Trisciuoglio, D., et al. PLoS ONE 5 (7), E11772 (2010) :
USBio References
No references available
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