Technical Data

032595
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_001116427.1; NP_001124174.1; NP_116056.3
Gene ID
26580
Gene #
BSCL2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-BSCL2, NT (BSCL2, Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein)
BSCL2, Seipin, Bernardinelli-Seip congenital lipodystrophy type 2 protein

This gene encodes protein seipin, which is located in the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
BSCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-115 amino acids from the N-terminal region of human BSCL2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rakocevic-Stojanovic, V., et al. J. Neurol. Sci. 296 (1-2), 107-109 (2010) :|Luigetti, M., et al. Muscle Nerve 42(3):448-451(2010)|Nishiyama, A., et al. Pediatr Int 51(6):775-779(2009)|Wu, Y.R., et al. J. Neurol. Neurosurg. Psychiatr. 80(10):1180-1181(2009)|Chen, W., et al. Endocrinology 150(10):4552-4561(2009)
USBio References
No references available
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