Technical Data

033146
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IF WB
Crossreactivity
Hu
Accession #
NP_001733.1
Gene ID
799
Gene #
CALCR
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-CALCR, CT (CALCR, Calcitonin receptor)
CALCR, Calcitonin receptor

CALCR is a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis.

Applications
Suitable for use in Western Blot, Immunofluorescence, Indirect Flow Cytometry and ELISA. Other applications have not been tested.
Recommended Dilution
Western Blot: 1:1000 Immunofluorescence: 1:10-1:50 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 445-474 in the C-terminal region of human CALCR
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human CALCR.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Nussenzveig, D.R., et al. Endocrinology 136(5):2047-2051(1995). 2. Nakamura, M., et al. Biochem. Biophys. Res. Commun. 209(2):744-751(1995). 3. Egerton, M., et al. J. Mol. Endocrinol. 14(2):179-189(1995). 4. Gorn, A.H., et al. J. Clin. Invest. 90(5):1726-1735(1992)
USBio References
No references available
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