033388
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
DB ECrossreactivity
HuAccession #
O95067;NP_004692.1Gene ID
9133Gene #
CCNB2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-CCNB2, phosphorylated (T359) (CCNB2, G2/mitotic-specific cyclin-B2)
CCNB2, G2/mitotic-specific cyclin-B2
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 colocalizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Applications
Suitable for use in Dot Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Dot blot 1:500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CCNB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T359 of human CCNB2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)|Haraguchi, T., et al. Fertil. Steril. 91 (4 SUPPL), 1424-1426 (2009) :|De Martino, I., et al. Cancer Res. 69(5):1844-1850(2009)|Bellanger, S., et al. Oncogene 26(51):7175-7184(2007)|Stav, D., et al. Int. J. Biol. Markers 22(2):108-113(2007)USBio References
No references available