Technical Data

033470
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001756.2
Gene ID
911
Gene #
CD1C
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-CD1C, CT (CD1C, T-cell surface glycoprotein CD1c, CD1c)
CD1C, T-cell surface glycoprotein CD1c, CD1c

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CD1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-253 amino acids from the C-terminal region of human CD1C.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :|Davila, S., et al. Genes Immun. 11(3):232-238(2010)|Garzon, D., et al. Mol. Immunol. 47 (2-3), 253-260 (2009) :|Van Rhijn, I., et al. J. Exp. Med. 206(6):1409-1422(2009)|Kaser, A., et al. Eur. J. Immunol. 38(8):2351-2359(2008)
USBio References
No references available
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