Technical Data

033856
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001020372.2
Gene ID
1123
Gene #
CHN1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-CHN1, NT (CHN1, ARHGAP2, CHN, N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, Rho GTPase-activating protein 2)
CHN1, ARHGAP2, CHN, N-chimaerin, A-chimaerin, Alpha-chimerin, N-chimerin, Rho GTPase-activating protein 2

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Volk, A.E., et al. Graefes Arch. Clin. Exp. Ophthalmol. 248(9):1351-1357(2010)|Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Miyake, N., et al. Am. J. Med. Genet. A 152A (1), 215-217 (2010) :|Murillo-Correa, C.E., et al. J AAPOS 13(3):245-248(2009)
USBio References
No references available
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