034210
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
ECrossreactivity
HuGene ID
1387Gene #
CREBBPShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-CREBBP, NT (CREB-binding protein, CREBBP, CBP, KAT3A)
CREB-binding protein, CREBBP, CBP, KAT3A
CREBBP is an acetyltransferase enzyme that acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 coactivator. This protein mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. CBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. For example, MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are also the cause of Rubinstein-Taybi syndrome (RSTS). RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Applications
Suitable for use in ELISA
Recommended Dilution
ELISA: 1:1,000
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Cui, Q., et al., Oncogene 24(24):3864-3874 (2005).|Gray, M.J., et al., Oncogene 24(19):3110-3120 (2005).|Mayr, B.M., et al., J. Biol. Chem. 280(15):15103-15110 (2005).|Roelfsema, J.H., et al., Am. J. Hum. Genet. 76(4):572-580 (2005).|Furumatsu, T., et al., J. Biol. Chem. 280(9):8343-8350 (2005).USBio References
No references available