Technical Data

034323
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_872580.1; NP_067021.1
Gene ID
58190
Gene #
CTDSP1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-CTDSP1, NT (CTDSP1, NIF3, NLIIF, SCP1, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, Small C-terminal domain phosphatase 1)
CTDSP1, NIF3, NLIIF, SCP1, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, Small C-terminal domain phosphatase 1

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
CTDSP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CTDSP1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Zhang, M., et al. Protein Sci. 19(5):974-986(2010)|Ji, H., et al. Plant J. 61(1):96-106(2010)|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Sapkota, G., et al. J. Biol. Chem. 281(52):40412-40419(2006)
USBio References
No references available
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