Technical Data

034488
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001014436.1; NP_001116428.1
Gene ID
28988
Gene #
DBNL
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-DBNL, CT (DBNL, CMAP, SH3P7, Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55kD, SH3 domain-containing protein 7)
DBNL, CMAP, SH3P7, Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55kD, SH3 domain-containing protein 7

Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
DBNL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-319 amino acids from the C-terminal region of human DBNL.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)|Haeckel, A., et al. J. Neurosci. 28(40):10031-10044(2008)|Le Bras, S., et al. FEBS Lett. 581(5):967-974(2007)|Lamesch, P., et al. Genomics 89(3):307-315(2007)|Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
USBio References
No references available
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