Technical Data

034591
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Mo
Accession #
NP_291040.1
Gene ID
116891
Gene #
Derl2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Derl2, CT (Derl2, Der2, Flana, Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa)
Derl2, Der2, Flana, Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :|Oda, Y., et al. J. Cell Biol. 172(3):383-393(2006)|Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102(40):14296-14301(2005)|Kaput, J., et al. Physiol. Genomics 18(3):316-324(2004)|Lilley, B.N., et al. Nature 429(6994):834-840(2004)
USBio References
No references available
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