Technical Data

034681
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_068770.2
Gene ID
1761
Gene #
DMRT1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-DMRT1, CT (DMRT1, DMT1, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1)
DMRT1, DMT1, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
DMRT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the C-terminal region of human DMRT1.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Kang, J.U., et al. Int. J. Oncol. 37(2):327-335(2010)|Turnbull, C., et al. Nat. Genet. 42(7):604-607(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Krentz, A.D., et al. Proc. Natl. Acad. Sci. U.S.A. 106(52):22323-22328(2009)|Cheng, H.H., et al. Cell Res. 16(4):389-393(2006)
USBio References
No references available
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