Technical Data

034761
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC IHC WB
Crossreactivity
Hu
Accession #
NP_003577.2
Gene ID
8448
Gene #
DOC2A
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-DOC2A, ID (DOC2A, Double C2-like domain-containing protein alpha)
DOC2A, Double C2-like domain-containing protein alpha

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.

Applications
Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Indirect Flow Cytometry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
DOC2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-314 amino acids from the Central region of human DOC2A.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)|Glessner, J.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10584-10589(2010)|Guilmatre, A., et al. Arch. Gen. Psychiatry 66(9):947-956(2009)|Kumar, R.A., et al. PLoS ONE 4 (2), E4582 (2009) :|Higashio, H., et al. J. Immunol. 180(7):4774-4784(2008)
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net