Technical Data

034800
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_057658.2; NP_000786.1
Gene ID
1813
Gene #
DRD2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-DRD2, CT (DRD2, D(2) dopamine receptor, Dopamine D2 receptor)
DRD2, D(2) dopamine receptor, Dopamine D2 receptor

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Applications
Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:2000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 307-336 in the C-terminal region of human DRD2. Species Sequence Homology: mouse.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human DRD2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Verma, V., et al. J. Biol. Chem. 285(45):35092-35103(2010). 2. Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010). 3. Stelzel, C., et al. J. Neurosci. 30(42):14205-14212(2010). 4. Huang, H.Y., et al. J. Formos. Med. Assoc. 109(10):736-739(2010). 5. Itokawa, M., et al. J. Pharmacol. Sci. 114(1):1-5(2010)
USBio References
No references available
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