034835
Clone Type
PolyclonalHost
RabbitSource
MouseIsotype
IgGGrade
Affinity PurifiedApplications
E IF IHC WBCrossreactivity
MoAccession #
NP_116760.2; NP_001383.2Gene ID
1837Gene #
DTNAShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-DTNA, CT (DTNA, DRP3, Dystrobrevin alpha, Alpha-dystrobrevin, Dystrophin-related protein 3)
DTNA, DRP3, Dystrobrevin alpha, Alpha-dystrobrevin, Dystrophin-related protein 3
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Immunofluorescence: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 691-721 amino acids from the C-terminal region of human DTNA.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Bohm, S.V., et al. BMC Biol. 7, 85 (2009) :|Nakamori, M., et al. Neurology 70(9):677-685(2008)|Lamesch, P., et al. Genomics 89(3):307-315(2007)|Lim, J., et al. Cell 125(4):801-814(2006)USBio References
No references available