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034888 Rabbit Anti-E2F2, ID (E2F2, Transcription factor E2F2)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
Q14209
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo
Accession #
NP_004082.1
Gene ID
1870
Gene #
E2F2
Shipping Temp
Blue Ice
Storage Temp
-20°C
E2F2, Transcription factor E2F2

E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq].

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
E2F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-297 amino acids from the Central region of human E2F2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human, mouse
References
Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)|Hayami, S., et al. Mol. Cancer 9, 59 (2010) :|Chen, J., et al. Cancer Causes Control 20(9):1769-1777(2009)|Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)|Lal, A., et al. Mol. Cell 35(5):610-625(2009)
USBio References
No references available
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