034919-APC
Clone Type
PolyclonalHost
RabbitSource
HumanConjugate
APCIsotype
IgGGrade
Affinity PurifiedApplications
FLISA IF IHC WBCrossreactivity
HuAccession #
NP_001946; P05305Gene ID
1906Gene #
EDN1Shipping Temp
Blue IceStorage Temp
4°C Do Not FreezeRabbit Anti-EDN1, CT (EDN1, Endothelin-1, Preproendothelin-1, Big endothelin-1) (APC)
EDN1, Endothelin-1, Preproendothelin-1, Big endothelin-1
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and FLISA. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 176-203 in the C-terminal region of human EDN1, UniProt Accession #P05305; NP_001946.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human EDN1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010) 2. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) 3. Feng, J., et al. Circulation 122 (11 SUPPL), S150-S155 (2010) 4. Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010) 5. Kaparianos, A., et al. Eur Rev Med Pharmacol Sci 14(8):705-719(2010)USBio References
No references available