Technical Data

034992
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_001160060.1; NP_065098.1
Gene ID
8891
Gene #
EIF2B3
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-EIF2B3, CT (EIF2B3, Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma)
EIF2B3, Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma

The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-441 amino acids from the C-terminal region of human EIF2B3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J. Phd, et al. Mol. Med. (2010) In press :|Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)|Maletkovic, J., et al. J. Child Neurol. 23(2):205-215(2008)|Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :|Mikami, S., et al. Protein Expr. Purif. 46(2):348-357(2006)
USBio References
No references available
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