035584-APC
Clone Type
PolyclonalHost
RabbitSource
HumanConjugate
APCIsotype
IgGGrade
Affinity PurifiedApplications
FLISA WBCrossreactivity
HuAccession #
NP_001121067.1; NP_001121064.1; NP_000560.5; NP_001121068.1; NP_001121065.1Gene ID
2214Gene #
FCGR3AShipping Temp
Blue IceStorage Temp
4°C Do Not FreezeRabbit Anti-FCGR3A, CT (FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, FcR-10, IgG Fc receptor III-2, CD16a) (APC)
FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, FcR-10, IgG Fc receptor III-2, CD16a
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot and FLISA. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 226-254 in the C-terminal region of human FCGR3A.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human FCGR3A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Dornan, D., et al., Blood 116(20): 4212-4222 (2010). 2. Li, S.C., et al., Am. J. Hematol. 85(10): 810-812 (2010). 3. Iwasaki, M., et al., Breast Cancer Res. Treat. 126(2): 497-505 (2011). 4. Qu, Y.H., et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4): 959-962 (2010). 5. Sfar, I., et al., Arch. Inst. Pasteur Tunis 86(1-4): 51-62 (2009).USBio References
No references available