Technical Data

035592
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E FC WB
Crossreactivity
Hu
Gene ID
83417
Gene #
FCRL4
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-FCRL4, CT (FCRL4, FCRH4, IFGP2, IRTA1, Fc receptor-like protein 4, Fc receptor homolog 4, IFGP family protein 2, Immune receptor translocation-associated protein 1, CD307d)
FCRL4, FCRH4, IFGP2, IRTA1, Fc receptor-like protein 4, Fc receptor homolog 4, IFGP family protein 2, Immune receptor translocation-associated protein 1, CD307d

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.

Applications
Suitable for use in Western Blot, ELISA and Indirect Flow Cytometry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:2000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 480-507 in the C-terminal region of human FCRL4.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human FCRL4.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Davila, S., et al. Genes Immun. (2010) In press : 2. Weiss, G.E., et al. J. Immunol. 183(3):2176-2182(2009) 3. Kazemi, T., et al. Cancer Immunol. Immunother. 58(6):989-996(2009) 4. Falini, B., et al. Blood 102(10):3684-3692(2003)
USBio References
No references available
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