035618
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_005108.1Gene ID
9965Gene #
FGF19Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-FGF19, CT (FGF19, Fibroblast growth factor 19)
FGF19, Fibroblast growth factor 19
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Applications
Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 175-202 in the C-terminal region of human FGF19, Swiss/UniProt Accession: O95750.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human FGF19.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Rao, A.S., et al. Gastroenterology 139(5):1549-1558(2010) 2. Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010) 3. Schreuder, T.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 98 (3), G440-G445 (2010) 4. Reiche, M., et al. Horm. Metab. Res. 42(3):178-181(2010) 5. Wu, X., et al. J. Biol. Chem. 285(8):5165-5170(2010)USBio References
No references available