035711-APC
Clone Type
PolyclonalHost
RabbitSource
HumanConjugate
APCIsotype
IgGGrade
Affinity PurifiedApplications
FLISA IHC WBCrossreactivity
HuAccession #
NP_000793.1Gene ID
2348Gene #
FOLR1Shipping Temp
Blue IceStorage Temp
4°C Do Not FreezeRabbit Anti-FOLR1, NT (FOLR1, FOLR, Folate receptor alpha, Adult folate-binding protein, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18) (APC)
FOLR1, FOLR, Folate receptor alpha, Adult folate-binding protein, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
Applications
Suitable for use in FLISA, Western Blot and Immunohistochemisty. Other potential application, though not tested is Direct Flow Cytometry. Other applications not tested.
Recommended Dilutions
Immunohistochemistry (Leica): Paraffin-embedded sections Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 33-68 in the N-terminal region of human FOLR1.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human FOLR1.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Sivakumaran, S., et al. J. Steroid Biochem. Mol. Biol. 122(5):333-340(2010). 2. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 3. O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010). 4. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010). 5. Elwood, P.C., et al. Biochemistry 36(6):1467-1478(1997)USBio References
No references available