Technical Data

035766
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Hu
Accession #
NP_001122298.1; NP_055101.2
Gene ID
23413
Gene #
NCS1
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-FREQ, NT (NCS1, FLUP, FREQ, Neuronal calcium sensor 1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein)
NCS1, FLUP, FREQ, Neuronal calcium sensor 1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
FREQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FREQ.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :|Handley, M.T., et al. PLoS ONE 5 (5), E10534 (2010) :|Torres, K.C., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 33(2):229-234(2009)|Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :|Kapp-Barnea, Y., et al. Mol. Biol. Cell 17(9):4130-4141(2006)
USBio References
No references available
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