035849
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E IHC WBCrossreactivity
Hu MoAccession #
O75899; NP_005449.5Gene ID
9568Gene #
GABBR2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-GABBR2, CT (GABBR2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51, HG20)
GABBR2, GPR51, GPRC3B, Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51, HG20
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:50-100
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 868-898 amino acids from the C-terminal region of human GABBR2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Oblak, A.L., et al. J. Neurochem. 114(5):1414-1423(2010)|Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :|Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :USBio References
No references available