Technical Data

035959
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_005249.1
Gene ID
2644
Gene #
GCHFR
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-GCHFR, CT (GCHFR, GFRP, GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulatory protein, p35)
GCHFR, GFRP, GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulatory protein, p35

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Applications
Suitable for use in Western Blot and ELISA. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 38-66 in the C-terminal region of human GCHFR. Species Sequence Homology: bovine
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A and peptide affinity chromatography.
Specificity
Recognizes human GCHFR.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. McHugh, P.C., et al. Pharmacogenomics J. (2010). 3. Li, L., et al. Circ. Res. 106(2):328-336(2010). 4. Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). 5. Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)
USBio References
No references available
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