036008
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_001486.4; NP_001158510.1; NP_001158511.1Gene ID
2675Gene #
GFRA2Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-GFRA2, CT (GFRA2, GDNFRB, RETL2, TRNR2, GDNF family receptor alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2)
GFRA2, GDNFRB, RETL2, TRNR2, GDNF family receptor alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GFRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-390 amino acids from the C-terminal region of human GFRA2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Souza, R.P., et al. J Psychiatr Res 44(11):700-706(2010)|Souza, R.P., et al. Psychopharmacology (Berl.) 210(3):347-354(2010)|Buysschaert, I.D., et al. Allergy 65(5):616-622(2010)|Lavedan, C., et al. Mol. Psychiatry 14(8):804-819(2009)|Volpi, S., et al. J Clin Psychiatry 70(6):801-809(2009)USBio References
No references available