Technical Data

036148
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_006424.2; NP_036615.2
Gene ID
10578
Gene #
GNLY
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-GNLY, NT (GNLY, LAG2, NKG5, TLA519, Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519)
GNLY, LAG2, NKG5, TLA519, Granulysin, Lymphokine LAG-2, Protein NKG5, T-cell activation protein 519

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GNLY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-43 amino acids from the N-terminal region of human GNLY.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Xing, J., et al. J. Immunol. 185(9):5074-5081(2010)|Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)|Davila, S., et al. Genes Immun. 11(3):232-238(2010)|Yang, C., et al. Int. J. Tuberc. Lung Dis. 13(11):1360-1366(2009)|Hogg, A.E., et al. J. Leukoc. Biol. 86(5):1191-1203(2009)
USBio References
No references available
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