036198
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
Hu MoAccession #
NP_001091671.1; NP_001496.1Gene ID
2852Gene #
GPERShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-GPER, CT (GPER, CEPR, CMKRL2, DRY12, GPR30, G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor)
GPER, CEPR, CMKRL2, DRY12, GPR30, G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GPER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human GPER.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Patel, V.H., et al. Int. J. Mol. Med. 26(2):193-199(2010)|Ignatov, A., et al. Breast Cancer Res. Treat. 123(1):87-96(2010)|Li, Y., et al. Mol. Endocrinol. 24(5):969-980(2010)|Kang, L., et al. Mol. Endocrinol. 24(4):709-721(2010)|Ariazi, E.A., et al. Cancer Res. 70(3):1184-1194(2010)USBio References
No references available