036289
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_015564.4; NP_000819.3Gene ID
2892Gene #
GRIA3Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-GRIA3, NT (GRIA3, GLUR3, GLURC, Glutamate receptor 3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3)
GRIA3, GLUR3, GLURC, Glutamate receptor 3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 188-217 in the N-terminal region of human GRIA3, UniProt Accession #P42263. |Species Sequence Homology: mouse, rat and monkey
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
Purity
Purified by Protein A affinity chromatography
Specificity
Recognizes human GRIA3.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Ripka, S., et al. Neoplasia 12(8):659-667 (2010). 2. Liu, Q., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(4):376-378 (2010). 3. Feyissa, A.M., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 34(2):279-283 (2010). 4. Marek, G.J., et al. Mol. Pharmacol. 77(3):317-326 (2010). 5. Formicola, D., et al. BMC Med. Genet. 11, 103 (2010) :USBio References
No references available