Technical Data

036294
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_786944.1; NP_068775.1; NP_001159719.1
Gene ID
2898
Gene #
GRIK2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-GRIK2, CT (GRIK2, GLUR6, Glutamate receptor, ionotropic kainate 2, Excitatory amino acid receptor 4, Glutamate receptor 6)
GRIK2, GLUR6, Glutamate receptor, ionotropic kainate 2, Excitatory amino acid receptor 4, Glutamate receptor 6

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GRIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 827-856 amino acids from the C-terminal region of human GRIK2.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Han, Y., et al. Biochemistry 49(43):9207-9216(2010)|Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)|Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Sampaio, A.S., et al. CNS Neurosci Ther (2010) In press :|Sander, T., et al. Neurology 45(9):1713-1720(1995)
USBio References
No references available
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