Technical Data

036295
Clone Type
Polyclonal
Host
Rabbit
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC WB
Crossreactivity
Mo
Accession #
NP_000822.2
Gene ID
2899
Gene #
GRIK3
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-GRIK3, NT (GRIK3, GLUR7, Glutamate receptor, ionotropic kainate 3, Excitatory amino acid receptor 5, Glutamate receptor 7)
GRIK3, GLUR7, Glutamate receptor, ionotropic kainate 3, Excitatory amino acid receptor 5, Glutamate receptor 7

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq].

Applications
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GRIK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-99 amino acids from the N-terminal region of human GRIK3.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Mouse

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :|Luciano, M., et al. Behav. Genet. 40(4):518-532(2010)|Kilic, G., et al. Psychiatry Res 175 (1-2), 43-46 (2010) :|Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)|Ahmad, Y., et al. World J. Biol. Psychiatry 10(4):330-333(2009)
USBio References
No references available
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