036466
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_034537.2; NP_001165588.1Gene ID
15162Gene #
HckShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-Hck, NT (Hck, Tyrosine-protein kinase HCK, B Cell/myeloid kinase, Hematopoietic cell kinase, Hemopoietic cell kinase, p56-HCK/p59-HCK)
Hck, Tyrosine-protein kinase HCK, B-cell/myeloid kinase, Hematopoietic cell kinase, Hemopoietic cell kinase, p56-HCK/p59-HCK
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Mouse Hck antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of Mouse Hck.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Verollet, C., et al. J. Immunol. 184(12):7030-7039(2010)|Ruschmann, J., et al. Exp. Hematol. 38(5):392-402(2010)|Lowell, C.A., et al. J. Cell Biol. 133(4):895-910(1996)|Lowell, C.A., et al. Blood 87(5):1780-1792(1996)|Avraham, K.B., et al. Genomics 13(2):264-268(1992)USBio References
No references available