036737
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
Affinity PurifiedApplications
E WBCrossreactivity
HuAccession #
NP_062458.1Gene ID
3234Gene #
HOXD8Shipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-HOXD8, CT (HOXD8, HOX4E, Homeobox protein Hox-D8, Homeobox protein Hox-4E, Homeobox protein Hox-5.4)
HOXD8, HOX4E, Homeobox protein Hox-D8, Homeobox protein Hox-4E, Homeobox protein Hox-5.4
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.
Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
HOXD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 242-270 amino acids selected from the C-terminal region of human HOXD8.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Ester, A.R., et al. Am. J. Med. Genet. A 149A (12), 2745-2752 (2009) :|Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)|Harada, K., et al. J. Cell. Sci. 122 (PT 21), 3923-3930 (2009) :|Goodman, F.R. Am. J. Med. Genet. 112(3):256-265(2002)|Kosaki, K., et al. Teratology 65(2):50-62(2002)USBio References
No references available