Technical Data

037034
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_060909.1
Gene ID
55364
Gene #
IMPACT
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-IMPACT, NT (IMPACT, Protein IMPACT, Imprinted and ancient gene protein homolog)
IMPACT, Protein IMPACT, Imprinted and ancient gene protein homolog

Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity).

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
IMPACT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human IMPACT.
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Habibi, D., et al. J. Cell. Physiol. 225(1):196-205(2010)|Davila, S., et al. Genes Immun. 11(3):232-238(2010)|Pereira, C.M., et al. J. Biol. Chem. 280(31):28316-28323(2005)|Okamura, K., et al. Biochem. Biophys. Res. Commun. 329(3):824-830(2005)|Okamura, K., et al. DNA Res. 11(6):381-390(2004)
USBio References
No references available
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